POLE and colorectal carcinoma: Our center currently offers a CRC gene panel consisting of 14 genes: APC, BMPR1A, MLH1, MSH2, MSH6, PMS2, MUTYH, NTHL1, POLD1 (exons 8–13), POLE (exons 9–14), PTEN, SMAD4, STK11, and GREM1 duplication.