In vivo PET imaging of cerebral tau accumulation in transgenic tauopathy mice has been achieved using [18F]PM-PBB3, [11C]PBB3, [11C]mPBB5, [18F]THK5117, [18F]JNJ-64349311, and 4R-tau specific tracers [18F]CBD-2115 [9, 32–40]. Here, MAPT is linked to tauopathy.