Abnormal cerebral deposition of pathological tau fibrils is a characteristic feature of tauopathy-related neurodegenerative diseases, including Alzheimer’s disease (AD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and parkinsonism linked to chromosome 17 [1]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.