To date, only AEA has been shown to play a key role in human embryo implantation (Maia et al. 2020), however, it is suspected that both OEA and PEA have an 'entourage effect' on levels of AEA (Bambang et al. 2010), where these molecules are preferentially degraded by the enzyme fatty acid amide hydrolase (FAAH), resulting in an aberrant increase in AEA concentration at the implantation site causing subsequent miscarriage (Maccarrone et al. 2001, Habayeb et al. 2008, Taylor et al. 2011). The gene discussed is FAAH; the disease is spontaneous abortion.