CRP and obesity due to melanocortin 4 receptor deficiency: Similarly, Sutterella (Proteobacteria) and C-reactive protein (CRP) – a marker of chronic low-grade systemic inflammation as seen in obesity, diabetes, heart disease and colorectal cancer (Zacarías et al. 2018); Ruminococcaceae/Lachnospiraceae and leptin; Bacteroidaceae and ghrelin; Coprococcus and gastrointestinal polypeptide (GIP) are directly related.