TP53 and central nervous system cancer: Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (“IDHmut”) are associated with increased risk of seizures, and IDHmut is nearly always found in conjunction with TP53 and ATRX mutations in astrocytomas, or TERT promoter mutations and 1p/19q codeletion in oligodendrogliomas.