GAS6 and osteoporosis: Therefore, the permanent consumption of vitamin K in diet impacts on MGP and Gas6 which are dependent on this vitamin and improve OA pathogenesis by changing in the process of osteoporosis and cartilage degradation.9 Additionally, vitamin K itself copes with inflammatory cytokines which are contributed to osteoporosis.32,33 Therefore, it could be concluded that the plasma level of phylloquinone is reversely associated with knee OA incidence.