Therefore, the permanent consumption of vitamin K in diet impacts on MGP and Gas6 which are dependent on this vitamin and improve OA pathogenesis by changing in the process of osteoporosis and cartilage degradation.9 Additionally, vitamin K itself copes with inflammatory cytokines which are contributed to osteoporosis.32,33 Therefore, it could be concluded that the plasma level of phylloquinone is reversely associated with knee OA incidence. This evidence concerns the gene MGP and osteoporosis.