PRTN3 and arthritic joint disease: Anaparti et al. evaluated the expression of miRNAs in whole blood as well as PBMCs, and observed that the levels of miR-103a-3p, miR-155, and miR-146a-5p were increased in both samples in RA patients as well as in the anticitrullinated protein antibodies (ACPA)-positive asymptomatic first-degree relatives (FDRs) without clinical presentations of arthritis.34 Our results also indicated that expression levels of miR-103a, miR-155, and miR-146a were higher in the whole blood of RA patients compared with healthy controls.