TNF-α produced in a local infection site allows macrophages, natural killer (NK) cells and γδ T cells gather at the infection site and bring their activation.26 The activated CTL cells have the ability to produce perforin protein and TNF-α by itself, which guide TB-infected monocytes to apoptosis, which involves intracellular living TB bacilli, and to induce the autophagy of infected cells via activated.24 Here, PRF1 is linked to tuberculosis.