In addition to the simulated level of perfusion recovery as the key model readout for tissue revascularization (which is a major focus in preclinical studies of PAD), our model describes several cellular and cytokine readouts (eg, number of total skeletal myocytes, tissue level of IFN-γ and TNF-α, muscle necrotic rate) that may be linked to the physiological and functional status of the recovering tissue postischemia. This evidence concerns the gene TNF and peripheral arterial disease.