SPRR2D and leukemia: In this leukemia cell, HSP arrested G0/G1 phase and enhanced DUSP1 (dual specificity phosphatase 1), DUSP3, DUSP5, CDK1A, CDK1B GADD45B, SPRR2D, MT1F, MT1A, p27Kip1, CASP4, NFKBIA gene expression at 100–150 μM concentration [107].