Dietary flavonoid HSP inhibits HER2 Tyrosine Kinase (HER2-TK) activity, causes MMP loss, chromatin condensation, activates caspase-8 and-3, resulting in cell cycle arrest at the G2 phase, which decreases the SKBR3 in MDA-MB-231 breast cancer cell growth [65]. Here, CASP8 is linked to breast cancer.