(2021) stated that the treatment of HSP in gastric cancer cells decreased cell migration and invasion by suppressing genes expression related to the metastatic and reducing disruptor of telemetric silencing 1-like (DOT1L) and the methylation of histone H3K79 in a gastric cancer cell by regulating the activity of CBP [98]. The gene discussed is DOT1L; the disease is hereditary spastic paraplegia.