HSP exhibits a cytotoxic mechanism towards multiple cancer cells such as breast cancer [9], pancreatic Cancer [10], prostate cancer [11], glioblastoma [12], liver cancer [13], kidney cancer [14], colon cancer [15], lung cancer [16], oral cancer [17], esophageal cancer [18], osteosarcoma [19], ovarian cancer [20], thyroid [21], leukemia [22] and some other cancers showing that HSP could be a promising cancer treatment candidate. Here, HSP90B2P is linked to osteosarcoma.