HSP-treated gastric cancer inhibited cell proliferation by inducing apoptosis by increasing Bax/Bcl-2 ratio, cyt-c,caspase-3, caspase-9, AIF, and Apaf-1 via a mitochondrial-dependent pathway in vitro and xenograft tumours at a dose-dependent manner [96]. This evidence concerns the gene CASP3 and gastric cancer.