Being a promising anticancer agent, HSP (100 μM) showed cytotoxicity on cells and prevented mammosphere, colony formation, and migration through elevating the mRNA level of p53, NOTCH1, PPARG, and reduced β-catenin resulted in apoptosis with cell cycle arrest G0/G1 phase in MCF-7 breast cancer cells [56]. Here, NOTCH1 is linked to breast cancer.