+IL-1a, IL-1b [2], LPS [2], nerve injury or inflammation (CCI, DMM, OA, microinjury at ligament flavum, monosodium urate), human disorder (FM, RA, intervertebral disc degeneration, degenerative lumbar spondylolisthesis, TMJ meniscus tears), infection (Candida albicans). The gene discussed is IL1A; the disease is rheumatoid arthritis.