+IL-1a, IL-1b [2], LPS [2], nerve injury or inflammation (CCI, DMM, OA, microinjury at ligament flavum, monosodium urate), human disorder (FM, RA, intervertebral disc degeneration, degenerative lumbar spondylolisthesis, TMJ meniscus tears), infection (Candida albicans). Here, IL1A is linked to Intervertebral disk degeneration.