ACE and breast carcinoma: Table 1 shows patient characteristics at the baseline before chemotherapy. There were no statistical differences in age, sex, and the usage of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers and β-blockers. The high D-dimer group included a lower rate of breast cancer (35 vs. 67%, p = 0.0005), a higher rate of ovarian/uterine cancer (19 vs. 6%, p = 0.0151), and a higher rate of leukemia (16 vs. 4%, p = 0.0068) than low D-dimer group. Echocardiographic data demonstrated that EF was slightly higher in the high D-dimer group (67 ± 5 vs. 64 ± 5%, p = 0.0019).