The main results are that (1) IGFBP-1 and IGFBP-1/IGF-1 ratio were significantly lower in patients with HF compared to those without HF, (2) in HF, IGF-1, IGFBP-1, and IGFBP-1/IGF-1 ratio did not differ among HFpEF, HFmrEF, and HFrEF, and (3) IGFBP-1 and IGFBP-1/IGF-1 ratio positively correlated with NT-proBNP. The gene discussed is NPPB; the disease is hydrops fetalis.