First of all, we preliminarily studied the expressions of TLRs in kidney cancer through ONCOMINE, and found that the expressions of TLR1, TLR2, TLR3, TLR4, TLR7 and TLR8 in kidney cancer were significantly higher than those in the corresponding normal tissues, while the expression of TLR5 was significantly lower in kidney cancer. Here, TLR4 is linked to kidney cancer.