AIM2 and immune system disorder: The upregulation of NEAT1 has been shown to promote the release of several inflammasomes (NLRP3, NLRC4, and AIM2) and pro-inflammatory cytokines (CXCL10, IL-6, and IL-1β), resulting in an immune response in inflammatory and immune diseases (Imamura et al., 2014; Zhang et al., 2016; Huang et al., 2017; Pandey et al., 2017; Huang et al., 2018; Prinz et al., 2019; Zhang et al., 2019).