The results suggested that these 13 genes, including CACNA1C, PALLD, FHL1, PDLIM3, SGCA, PGM5, FERMT2, DMD, MYOCD, CALD1, CNN1, MYLK and SMTN, were more crucial to the pathogenesis of bladder cancer. The gene discussed is MYLK; the disease is urinary bladder cancer.