We found that double-high group cells potentially stimulated tumor growth and metastasis through angiogenesis signaling molecules (VEGFA-ITGB1, VEGFA-EGFR, VEGFA-ITGAV) (Maae et al., 2012; Chou et al., 2013; Kim et al., 2017; Sullivan et al., 2019). Here, ITGB1 is linked to neoplasm.