One gene we identified as being misexpressed after phc depletion was that encoding the nuclear factor onecut1, a CUT and homeobox domain-containing transcription factor that promotes hepatocyte proliferation, remodels chromatin accessibility, and promotes tumor growth in colorectal cancers (Jiang et al., 2019; van der Raadt et al., 2019; Peng et al., 2020). Here, CUX1 is linked to colorectal cancer.