Caspase-1 knockout reduced the viability of BV2 microglia, but not LDH release, and increased IL-1β levels, which not only affected the function of sevoflurane but also indicated that microglia-derived IL-1β causes tauopathy deterioration, as observed with other tau kinases (Bhaskar et al., 2010). The gene discussed is IL1B; the disease is tauopathy.