The two main pathological hallmarks of AD include the deposition of amyloid-β (Aβ) in senile plaques and the formation of neurofibrillary tangles due to pathological changes in microtubule-associated proteins, such as tau (Maloney and Lahiri, 2011; Douchamps and Mathis, 2017; Flores et al., 2018). Here, MAPT is linked to Alzheimer disease.