Although sevoflurane induced caspase-1-dependent pyroptosis by activating NLRP3 inflammasomes in both the WT and model groups, leading to inflammation and tau pathology, sevoflurane exerted stronger effects in the model group, supporting the hypothesis that anesthesia via inhalation may increase the risk of AD in those with a genetic predisposition (Xu et al., 2018; Xu et al., 2019). Here, MAPT is linked to Alzheimer disease.