According to the risk value of each gene, ZFPM2, ZNF560, ZSCAN4, HMX2, HRASLS, LGALS1, LHX6, CCL23, and FAM155B were regarded as risk genes related to poor prognosis in patients with AML, whereas MXRA5, PCDHB12, PRINS, TMEM56, TWIST1, ASTN1, DLL3, EFNB3, and FOXL1 were associated with favorable prognosis. The gene discussed is DLL3; the disease is acute myeloid leukemia.