The results indicated that compared with the control (si-NC), the silence of PTPN6 and PSMB8 significantly suppressed cell growth (Figure 9B and Supplementary Figure S11B; p < 0.05), and the formation of tumor cell colonies (Figure 9C and Supplementary Figure S11C; p < 0.01). The gene discussed is PSMB8; the disease is neoplasm.