TTN and neoplasm: Mutational analysis showed that the adenomatous polyposis coli (APC), tumor suppressor P53 (TP53), KRAS proto-oncogene GTPase (KARS), titin (TTN), spectrin repeat containing nuclear envelope protein 1 (SYNE1), mucin 16 (MUC16), and low-density lipoprotein receptor-related protein 1B (LRP1B) were the most frequently mutated genes in the fraction genome alteration and tumor mutational count group (Figures 1D,E).