Studies support a single m6A regulator participating in the immune-associated colitis-like methyltransferase 14 (METTL14) deletion in T-cells trigger spontaneous colitis (Lu et al., 2020), and m6A reader ELAV-like RNA binding protein 1 (ELAVL1, also known as HuR) maintain colonic epithelial Paneth cells’ function (Xiao et al., 2019; Xu et al., 2021; Zhang et al., 2021). The gene discussed is METTL14; the disease is colitis.