PNPO and pancreatic adenocarcinoma: The highest gene alteration rate of PNPO appears for pan-cancer patients with uterine corpus endometrial carcinoma, uterine carcinosarcoma, breast invasive carcinoma, pancreatic adenocarcinoma, and mesothelioma with amplification (>2%) as the primary type using the cBioPortal database (Figure 4A).