TAMs not only degrade the ECM but also promote epithelial–mesenchymal transition and invasiveness of tumor cells through secretion of TGF-β and growth factors, such as EGF analogs (Kessenbrock et al., 2010; Mason and Joyce, 2011; Bonde et al., 2012; Hanahan and Coussens, 2012). Here, TGFB1 is linked to neoplasm.