TP53 and familial pancreatic carcinoma: Point mutations within the p53 gene have been detected in many cancer types including 30% of GBM, 67.4% of pancreatic cancer, and up to 90% of ovarian serous cystadenocarcinoma and pulmonary squamous cell carcinomas (Cancer Genome Atlas Resea, 2011; Cancer Genome Atlas Resea, 2012; Kanda et al., 2013).