In contrast, M2 TAMs release immunosuppressive cytokines, such as CCL2, CCL17, CCL18, CCL22, and CCL24 which drive a reduction of cytotoxic T cell activation and proliferation to promote tumor progression (Mantovani et al., 2013; Shapouri-Moghaddam et al., 2018). Here, CCL2 is linked to neoplasm.