Moreover, 10 hub targets (MMP9, IL1β, IFNG, IL10, ICAM1, CCL2, PTGS2, IL6, CXCL8, and JUN) of HLJDD in treating RA were identified through constructing the PPI network of the 41 common targets from HLJDD and RA. This evidence concerns the gene ICAM1 and rheumatoid arthritis.