Prostaglandin-endoperoxide synthase 2 (PTGS2), also called COX-2, has been recognized as a significant proinflammatory target of RA, and COX-2 inhibitor (NSAIDs) was the preferred anti-inflammatory drug to control pain and stiffness (Crofford, 2013). This evidence concerns the gene PTGS2 and rheumatoid arthritis.