PTGS2 and rheumatoid arthritis: These targets were significantly enriched in the biological process of the cellular inflammatory response to different substances such as organic substance and chemical and cytokine stimulus and associated with IL-17 signaling pathway (CCL2, CXCL10, CXCL8, IFN-γ, IL1β, IL6, JUN, MMP9, PTGS2), TNF signaling pathway (CCL2, CXCL10, ICAM1, IL1β, IL6, JUN, MMP9, PTGS2), rheumatoid arthritis pathway (CCL2, CXCL8, ICAM1, IFNG, IL1β, IL6, JUN), and Toll-like receptor signaling pathway (CXCL10, CXCL8, IL1β, IL6, JUN).