HTR1A and major depressive disorder: At present, the medication for depression management largely relies on the chemical-based drugs that are categorized into selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tetracyclic antidepressants, dopamine reuptake blockers, monoamine oxidase inhibitors (MAOIs), 5-HT receptor (5-HT1A, 5-HT2, and 5-HT3) and noradrenergic antagonists (Alvano and Zieher, 2020).