We intersected the key genes related to aneuploidy found in methylation profile with genes in RNA-seq profile, which led to 11 potential driver genes regulated by anomalous DNA methylation in PCa (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2) (Figure 5D). Here, HAAO is linked to posterior cortical atrophy.