HIF3A and posterior cortical atrophy: We intersected the key genes related to aneuploidy found in methylation profile with genes in RNA-seq profile, which led to 11 potential driver genes regulated by anomalous DNA methylation in PCa (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2) (Figure 5D).