In conclusion, we systematically demonstrated the molecular process of aneuploidy in PCa and identified 11 potential driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2). The gene discussed is HIF3A; the disease is posterior cortical atrophy.