SPOP and posterior cortical atrophy: In the mutation profile, we identified a recurrent gene mutation in PCa using the OncodriveCLUST (54) algorithm implemented in maftools (Mayakonda et al., 2018) package, which distilled CTNNB1, IDH1, SPOP, BRAF, and PIK3CA with a threshold of adjusted p-value < 0.05 (Figure 5A).