With regard to these 11 driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2), all of which were hyper-methylated and hypo-expressed in PCa; Cox analysis confirmed their prognostic implications (except GSTM2). The gene discussed is HFE; the disease is posterior cortical atrophy.