We intersected the key genes related to aneuploidy found in methylation profile with genes in RNA-seq profile, which led to 11 potential driver genes regulated by anomalous DNA methylation in PCa (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2) (Figure 5D). The gene discussed is HFE; the disease is posterior cortical atrophy.