In conclusion, we systematically demonstrated the molecular process of aneuploidy in PCa and identified 11 potential driver genes (GSTM2, HAAO, C2orf88, CYP27A1, FAXDC2, HFE, C8orf88, GSTP1, EFS, HIF3A, and WFDC2). This evidence concerns the gene CYP27A1 and posterior cortical atrophy.