HIF1A and gastric cancer: Consistent with this hypothesis, pharmacological blockade of glycolysis reversed the effects of circNRIP1 on hypoxia-induced 5-FU resistance in GC cells, suggesting that circNRIP1 had emerged as an important regulator of hypoxia-induced chemoresistance via HIF-1α-mediated glucose metabolism in GC by targeting miR-138-5p (Xu et al., 2020).