In this work and for further progressing in our research program on the discovery of new coumarin derivatives as MTDLs against AD (Jalili-Baleh et al., 2018a; Salehi et al., 2019), we prepared new 3-arylcoumarin derivatives bearing N-benzyl triazole substructures (Figure 1) to target 15-LOX and ChEs, with neuroprotection activity and anti-Aβ aggregation activity, simultaneously. The gene discussed is LOX; the disease is Alzheimer disease.