It shows anti-oxidative and anti-inflammatory effects that alleviate the adverse consequences of the periodontal disease such as lower generation of NO (Rizzo et al., 2012), excessive expression of vascular endothelial growth factor (VEGF) by human gingival fibroblasts, and reduced permeability of vessels (Núñez et al., 2010). This evidence concerns the gene VEGFA and periodontal disorder.