SLC26A3 and congenital secretory chloride diarrhea 1: Congenital chloride diarrhea (CLD) is a rare autosomal recessive (AR) disorder caused by a mutation in SLC26A3(Solute carrier family 26, member3) gene that encodes for Down Regulated in Adenoma (DRA), an intestinal Na+ independent Cl−/HCO3- (or OH−) exchanger (1).