However, we noted an increase in mRNA read abundance of these transcripts in our RNAseq study (Havranek et al., 2019), indicating either that RIOK3 and TRA2-β mRNA abundance is not affected by NSs transcriptional shutdown in the time frame of acute infection, and/or that the relative abundances of splicing isoforms of these mRNAs exerts a more powerful effect than their absolute copy numbers. Here, RIOK3 is linked to infection.