The RIOK3 constitutive-to-alternative splicing pattern was also consistently observed during RVFV infection of multiple cell lines, including HEK293 (human embryonic kidney), HeLa (human cervical carcinoma), SH-SY5Y (human neuroblastoma), HepG2 and HC-04 (human hepatoma), HFF-1 (transformed human foreskin fibroblasts), and Vero (African green monkey kidney) (Figure 1C). The gene discussed is RIOK3; the disease is hepatocellular carcinoma.