Captivatingly, vancomycin and the antibiotic cocktail reshaped the gut microbiome and the correlation analysis suggests the importance of gram-positive bacteria Allobaculum, Bifidobacterium, and Ruminococcus depletion in the reversal of IR and dyslipidemia in iNOS−/− mice with a seemingly less important role of gram-negative bacteria in the redox imbalanced state. Here, NOS2 is linked to metabolic syndrome.