In hepatocellular carcinoma, the study has reported that miR-30a markedly decreased in hepatocellular carcinoma (HCC) tissues and cell lines, overexpression of miR-30a restrain the lung cancer cell proliferation and migration, a further study has shown that miR-30a by down-regulated the expression of Atg5 and lead to inhibits hepatocellular carcinoma (HCC) metastasis (6). The gene discussed is ATG5; the disease is hepatocellular carcinoma.