SOX2 and cancer: Previous KEGG analysis show that miR-30a-5p target gene may participate in the Wnt signaling pathway, to further characterize the function of miR-30a-5p regulates LUAD cancer stem cell maintenance, we performed correlation analysis and showed that miR-30a-5p negative correlated with the expressions of well define cancer stem cell marker genes, including CD44, Sox2, Oct4 and NANOG (Figure 9A) (14).