In case reports, heavily pretreated BRAF V600E-mutated multiple myeloma patients experienced durable responses with either the BRAF inhibitor vemurafenib alone and vemurafenib plus the MEK inhibitor cobimetinib and served as proof-of-concept for the efficacy of BRAF inhibition in multiple myeloma (13, 16). The gene discussed is BRAF; the disease is AL amyloidosis.