TLR4 activation leads to NF-κB-mediated signaling and production of inflammatory cytokines and chemokines such as IL-6, IL-8, CXCL-1 and CXCL-10 in melanocytes (94) and IL-8 and MMP-2 secretion in melanoma cells (110). The gene discussed is CXCL8; the disease is melanoma.