In this study, PDGF -induced HAS2 upregulation associated with activated phenotype of fibroblasts with elongated morphology, upregulation of proteolytic enzyme MMP1, MMP9 and MT1-MMP expressions and increased invasion into the matrix, suggesting that HAS2 is essential in activating the fibroblasts in the tumor stroma (104). The gene discussed is HAS2; the disease is neoplasm.