Further characterization of PIEZO1 as a central hub in a mechanotransduction cascade revealed subcellular location of the channel at sites of focal adhesion and a feed-forward mechanism whereby PIEZO1 was shown to be essential for ECM stiffening via regulation of other ECM remodeling genes including TAZ and FHL3 as well as glioma cell mechanotransduction (71). Here, PIEZO1 is linked to central nervous system cancer.