analyzing the expression of GBM PIEZO1 relative to normal peritumoral tissue in patients; quantification of PIEZO1 expression and image analysis revealed a positive relationship between expression and extent of peritumoral edema where higher expression was observed in patients with severe edema that was defined as an edema index >3 (calculated as the ratio of tumor and edema volume to tumor volume) (82). Here, PIEZO1 is linked to neoplasm.