It has been shown (10) that the ADC mean value is related to the expression level of Ki-67 and p53 in esophageal squamous cell carcinoma, which can be used as a noninvasive biological indicator to predict the proliferation of esophageal squamous cell carcinoma cells and to determine the prognosis of patients. The gene discussed is TP53; the disease is esophageal squamous cell carcinoma.