Propofol attenuated the decrease in CD39 and CD73 in circulating CD4+ T cells compared to sevoflurane-based anesthesia in patients undergoing open heart surgeries (23), while similar comparative studies have not been reported in breast cancer patients despite that circulating regulatory T cells has been recently reported to be significantly increased in breast cancer patients which may impact on the stage and histological type of breast cancer (24). Here, CD4 is linked to breast carcinoma.