Finally, HPGD which encodes the PGE2 signal terminator 15-PGDH is significantly upregulated in the CD44+/CD24- tumor cells; this could negate any increased production of PGE2 cells due to increased PLA2/COX-2, since increased 15-PGDH would degrade produced PGE2. The gene discussed is HPGD; the disease is neoplasm.