The mean DLX6-AS1 methylation levels could distinguish primary lesions from their adjacent normal mucosa, with AUC values of 0.944 (95% CI: 0.922-0.962), 0.811 (95% CI: 0.739-0.870) and 0.767 (95% CI: 0.688-0.834) for CRC, AA and NAA, respectively (Figure 5). Here, DLX6 is linked to colorectal carcinoma.