ROC curve analyses revealed that methylation status of each individual genes could significantly distinguish primary carcinoma from adjacent normal mucosa, as measured by AUC value (DLX6-AS1: 0.941; lnc-DPH5-1: 0.833; lnc-PRSS2-6: 0.913; lnc-RPS12-6: 0.916; lnc-SFRP4-2: 0.830; SOX21-AS1: 0.921) (Figure 4G). Here, PRSS2 is linked to carcinoma.