Lnc-HoxBlinc can be combined with the promoter region of the characteristic gene of NPM1c, through MLL1 recruitment and promoter H3K4me3 modification to control their activation in HoxBlincTg HSPC, and then act as a cancer-promoting factor to cause the malignant progression of acute myeloid leukemia (AML) (88). Here, KMT2A is linked to acute myeloid leukemia.