While our discovery of SID7969543 as a selective inhibitor of KMT2A-r leukemia highlights NR5A1 as a candidate target in KMT2A-r leukemia, the absence of a phenotypic effect of NR5A1 silencing by siRNA and the lack of a similar KMT2A-r selective cytotoxicity of another structurally dissimilar inverse NR5A1 agonist suggests that it is unlikely that the inhibition of NR5A1 solely explains the selective killing of KMT2A-r leukemia cells by SID7969543. The gene discussed is NR5A1; the disease is leukemia.