As mentioned above, prostate cancer is exceedingly lipogenic, highlighted by accelerated de novo synthesis of fatty acids driven by enhanced activity of sterol regulatory element-binding protein (SREBP) (70, 71), which induces the transcription of many genes involved in lipid metabolism, including ACLY, ACACA, FASN, SCD1 and LDLR (72). Here, FASN is linked to Familial prostate cancer.