As mentioned above, prostate cancer is exceedingly lipogenic, highlighted by accelerated de novo synthesis of fatty acids driven by enhanced activity of sterol regulatory element-binding protein (SREBP) (70, 71), which induces the transcription of many genes involved in lipid metabolism, including ACLY, ACACA, FASN, SCD1 and LDLR (72). The gene discussed is ACLY; the disease is prostate cancer.