Increased expression of PLOD2 has been found in many types of cancer including breast cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, etc. (26) In HNSCC, PLOD2 is essential for the invasion and metastasis by activating the function of integrin β1 (27). This evidence concerns the gene PLOD2 and hepatocellular carcinoma.