Increased expression of PLOD2 has been found in many types of cancer including breast cancer, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, etc. (26) In HNSCC, PLOD2 is essential for the invasion and metastasis by activating the function of integrin β1 (27). The gene discussed is PLOD2; the disease is esophageal squamous cell carcinoma.