The qPCR and Western blotting results indicated that Sohlh2 overexpression inhibited the EMT of RCC; that is, Sohlh2 overexpression upregulated the expression levels of epithelial markers of E-cadherin, ZO-1, and Claudin and downregulated the expression levels of mesenchymal markers of ZEB-1, Vimentin, and Fibronectin. This evidence concerns the gene SOHLH2 and renal cell carcinoma.