The CYP2C18, INPP4B, and NT5E expression levels were examined in six PC cell lines (AsPC-1, BxPC-3, Capan-2, MIA PaCa-2, PANC-1, and SW1990) and normal pancreas epithelial cells (HPC-Y5) was used as control. The gene discussed is INPP4B; the disease is pachyonychia congenita.