Currently, there are more than 15 clinical staging systems including these prognostic factors, such as the (1) American Joint Commission on Cancer (AJCC) seventh edition (5), (2) the Barcelona Clinic Liver Cancer (BCLC) system (6), (3) Cancer of the Liver Italian Program (CLIP) system (7), (4) Japan Integrated Staging Score (JIS) system (8), (5) Okuda staging system (9), (6) Vauthey’s system (10), (7) the albumin-bilirubin (ALBI) grading system (11), and (8) the Hong Kong Liver Cancer staging system (12). This evidence concerns the gene ALB and liver cancer.