TGFB1 and Myocardial fibrosis: TGFβ1 is apotent stimulator of extracellular matrix production; its hyperproduction isassociated with fibrotic disorders and the development of myocardial fibrosis.Leask [16] showed that TGFβ addedto a fibroblast culture in vitro induces the expression of the genes related toextracellular matrix production and thus increases matrix accumulation andcontributes to a concomitant suppression of matrix metalloproteinase productionby raising the level of inhibitors of the gene encoding its expression.