When analyzing the genetic predisposition to the primary disease that had beenresponsible for the end-stage heart failure and had made it necessary toperform heart transplantation, we observed a significant association betweenischemic heart disease and the rs1800469 single nucleotide polymorphism.Similar data were obtained by Barsova et al. [4], who found a positive association between the TGFB1*-509T(rs1800469) allele and genetic predisposition to early myocardial infarction(in patients younger than 50 years). This evidence concerns the gene TGFB1 and heart disorder.